Flow injection chemiluminescence determination of loxoprofen and naproxen with the acidic permanganate-sulfite system

被引：19
作者：
Wang, Li-Juan [1 ,2 ]
Thng, Yu-Hai [2 ]
Liu, Yang-Hao [2 ]
机构：
[1] Xi An Jiao Tong Univ, Med Sch, Xian 710061, Peoples R China
[2] Xi An Jiao Tong Univ, Inst Analyt Sci, Xian 710061, Peoples R China
来源：
JOURNAL OF PHARMACEUTICAL ANALYSIS | 2011年 / 1卷 / 01期
关键词：
chemiluminescence; KMnO4; loxoprofen; naproxen;
D O I：
10.1016/S2095-1779(11)70009-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A novel flow injection chemiluminescence (CL) method for the determination of loxoprofen and naproxen was proposed based on the CL system of KMnO4 and Na2SO3 in acid media. The CL intensity of KMnO4 - Na2SO3 was greatly enhanced in the presence of loxoprofen and naproxen. The mechanism of the CL reaction was studied by the kinetic process and UV-vis absorption and the conditions were optimized. Under optimized conditions, the CL intensity was linear with loxoprofen and naproxen concentration in the range of 7.0 X 10(-8) - 1.0 x 10(-5) g/mL and 2.0 x 10(-7) - 4.0 X 10(-5) g/mL with the detection limit of 2.0 x 10(-8) g/mL and 3.0 x 10(-8) g/mL (S/N = 3), respectively. The relative standard deviations were 2.39% and 1.37% for 5.0 x 10(-7) g/mL naproxen and 5.0 x 10(-7) g/mL loxoprofen (n = 10), respectively. The proposed method was satisfactorily applied to the determination of loxoprofen and naproxen in pharmaceutical preparations.
引用
收藏
页码：51 / 56
页数：6
相关论文
共 31 条
[1]  
Aboul-Enein Hassan Y., 2003, Farmaco (Lausanne), V58, P419
[2]   Acidic potassium permanganate as a chemiluminescence reagent-A review [J].
Adcock, Jacqui L. ;
Francis, Paul S. ;
Barnett, Neil W. .
ANALYTICA CHIMICA ACTA, 2007, 601 (01) :36-67
[3]  
Brooks P., 1998, AM J MED, V104, p9S, DOI DOI 10.1016/S0002-9343(97)00204-0
[4]   In vitro monitoring of nanogram levels of naproxen in human urine using flow injection chemiluminescence [J].
Cheng, XL ;
Zhao, LX ;
Liu, ML ;
Lin, JM .
ANALYTICA CHIMICA ACTA, 2006, 558 (1-2) :296-301
[5]   Determination of flunixin and ketoprofen in milk by liquid chromatography-tandem mass spectrometry [J].
Daeseleire, E ;
Mortier, L ;
De Ruyck, H ;
Geerts, N .
ANALYTICA CHIMICA ACTA, 2003, 488 (01) :25-34
[6]   Non-steroidal anti-inflammatory drugs to potentiate chemotherapy effects: From lab to clinic [J].
de Groot, D. J. A. ;
de Vries, E. G. E. ;
Groen, H. J. M. ;
de Jong, S. .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2007, 61 (01) :52-69
[7]   First interlaboratory exercise on non-steroidal anti-inflammatory drugs analysis in environmental samples [J].
Farre, M. ;
Petrovic, M. ;
Gros, M. ;
Kosjek, T. ;
Martinez, E. ;
Heath, E. ;
Osvald, P. ;
Loos, R. ;
Le Menach, K. ;
Budzinski, H. ;
De Alencastro, F. ;
Mueller, J. ;
Knepper, T. ;
Fink, G. ;
Ternes, T. A. ;
Zuccato, E. ;
Kormali, P. ;
Gans, O. ;
Rodil, R. ;
Quintana, J. B. ;
Pastori, F. ;
Gentili, A. ;
Barcelo, D. .
TALANTA, 2008, 76 (03) :580-590
[8]   Determination of acidic pharmaceuticals and potential endocrine, disrupting compounds in wastewaters and spring waters by selective elution and analysis by gas chromatography-mass spectrometry [J].
Gibson, Richard ;
Becerril-Bravo, Elias ;
Silva-Castro, Vanessa ;
Jimenez, Blanca .
JOURNAL OF CHROMATOGRAPHY A, 2007, 1169 (1-2) :31-39
[9]   Interaction of indomethacin and naproxen with gastric surface-active phospholipids: A possible mechanism for the gastric toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs) [J].
Giraud, MN ;
Motta, C ;
Romero, JJ ;
Bommelaer, G ;
Lichtenberger, LM .
BIOCHEMICAL PHARMACOLOGY, 1999, 57 (03) :247-254
[10]  
Growka FK, 2004, J PHARM BIOMED ANAL, V35, P807
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