CIRCADIAN EXPRESSION OF TRANSCRIPTION FACTOR FRA-2 IN THE RAT PINEAL-GLAND

被引：87

作者：

BALER, R ^{[1
]}

KLEIN, DC ^{[1
]}

机构：

[1] NICHHD,DEV NEUROBIOL LAB,NEUROENDOCRINOL SECT,BETHESDA,MD 20892

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1995年 / 270卷 / 45期

关键词：

D O I：

10.1074/jbc.270.45.27319

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Physiological changes in Fos-like immunoreactivity in the rat pineal gland are shown here to be due primarily to changes in a 42/46-kDa Fos-related antigen (Era). Studies are presented that indicate this 42/46-kDa Fra is Fra-2, a poorly understood member of the Fos family of transcription factors. Both Fra-2 mRNA and protein are absent during the day and increase robustly at night on a circadian basis; organ culture studies indicate that regulation is mediated by an adrenergic --> cyclic AMP mechanism. AP-1 binding activity changes in parallel to changes in the level of Fra a protein.

引用

页码：27319 / 27325

页数：7

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