THE SEARCH FOR INOSINE 5'-PHOSPHATE DEHYDROGENASE (IMPDH) INHIBITORS FROM MARINE SPONGES - EVALUATION OF THE BASTADIN ALKALOIDS

被引：45

作者：

JASPARS, M

RALI, T

LANEY, M

SCHATZMAN, RC

DIAZ, MC

SCHMITZ, FJ

PORDESIMO, EO

CREWS, P

机构：

[1] UNIV CALIF SANTA CRUZ,DEPT CHEM & BIOCHEM,SANTA CRUZ,CA 95064

[2] UNIV CALIF SANTA CRUZ,INST MARINE SCI,SANTA CRUZ,CA 95064

[3] UNIV OKLAHOMA,DEPT CHEM,NORMAN,OK 73019

[4] SYNTEX INC,DISCOVERY RES,INST BIOCHEM & CELL BIOL,PALO ALTO,CA 94304

来源：

TETRAHEDRON | 1994年 / 50卷 / 25期

关键词：

D O I：

10.1016/S0040-4020(01)90467-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Six known bastadins, compounds 1 - 6, and one new one, bastadin 18 (g), have been isolated from the marine sponge Ianthella Basta collected in Papua New Guinea. A mixture of compounds 2 and 3 was also isolated from I. flabelliformis. Two of these compounds, bastadins 8 (5) and 10 (6), were found to be moderate inhibitors of IMPDH. A discussion of the enzyme assay is included.

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页码：7367 / 7374

页数：8

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