NEONATAL BLOOD-GLUCOSE CONCENTRATIONS - METABOLIC EFFECTS OF INTRAVENOUS GLUCAGON AND INTRAGASTRIC MEDIUM CHAIN TRIGLYCERIDE

被引:23
作者
HAWDON, JM [1 ]
AYNSLEYGREEN, A [1 ]
PLATT, MPW [1 ]
机构
[1] UNIV NEWCASTLE UPON TYNE, DEPT CHILD HLTH, NEWCASTLE UPON TYNE NE1 7RU, TYNE & WEAR, ENGLAND
来源
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION | 1993年 / 68卷 / 03期
关键词
D O I
10.1136/adc.68.3_Spec_No.255
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Neonatal hypoglycaemia is a common clinical problem and the traditional treatment for the condition is intravenous glucose administration. The glycaemic effects of two additional treatments were investigated, in a randomised trial, in 23 neonates who were receiving intravenous glucose as treatment for hypoglycaemia. Eleven infants received an intravenous bolus dose of glucagon (200 mug/kg) and 12 infants received intragastric medium chain triglyceride (MCT) (5 ml/kg). Blood concentrations of glucose and intermediary metabolites were measured before and one hour after treatment, and, using stable isotope infusion, glucose production rates were calculated. After glucagon, there was a mean rise in blood glucose concentration of 1.6 mmol/l and in the glucose production rate of 2.6 mg/kg/min. After MCT, there was a small mean rise in blood glucose concentration of 0.4 mmol/l, but the effect of MCT on glucose production rate was variable. Intravenous bolus glucagon administration exerted a glycaemic effect which was associated with an increase in glucose production rate. The use of glucagon, as an alternative treatment to intravenous glucose, should be investigated further.
引用
收藏
页码:255 / 261
页数:7
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