ENTERIC NON-A, NON-B HEPATITIS - EPIDEMICS, ANIMAL TRANSMISSION, AND HEPATITIS-E VIRUS DETECTION BY THE POLYMERASE CHAIN-REACTION

被引：90

作者：

JAMEEL, S

DURGAPAL, H

HABIBULLAH, CM

KHUROO, MS

PANDA, SK

机构：

[1] ALL INDIA INST MED SCI, DEPT PATHOL, NEW DELHI 110029, INDIA

[2] INT CTR GENET ENGN & BIOTECHNOL, VIROL GRP, NEW DELHI, INDIA

[3] OSMANIA GEN HOSP, DEPT GASTROENTEROL, HYDERABAD, INDIA

[4] SHERIKASHMIR INST MED SCI, DEPT GASTROENTEROL & MED, SRINAGAR, INDIA

来源：

JOURNAL OF MEDICAL VIROLOGY | 1992年 / 37卷 / 04期

关键词：

HEV; PCR; EPIDEMIC; HEPATITIS; BILE; TRANSMISSION;

D O I：

10.1002/jmv.1890370405

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We studied epidemics of viral hepatitis occurring at three different places in India. One was a combined epidemic due to hepatitis E virus (HEV) and hepatitis A virus (HAV) infections. In this epidemic, HAV affected children below 10 years of age, whereas HEV infected the young adult population. HEV was transmitted to rhesus monkeys (Macaca mulata) and confirmed by the polymerase chain reaction (PCR) on bile from the animals. Fecal material from acutely infected patients in one of the epidemics was also found positive for HEV RNA by PCR. This may help in confirming the nature of future epidemics. The bile and liver from experimental animals can be used as a source of material for further virological and molecular biological studies of HEV.

引用

页码：263 / 270

页数：8

共 22 条

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