BRLA REQUIRES BOTH ZINC FINGERS TO INDUCE DEVELOPMENT

被引：45

作者：

ADAMS, TH ^{[1
]}

DEISING, H ^{[1
]}

TIMBERLAKE, WE ^{[1
]}

机构：

[1] UNIV GEORGIA, DEPT GENET, ATHENS, GA 30602 USA

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 04期

关键词：

D O I：

10.1128/MCB.10.4.1815

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of the Aspergillus nidulans brlA gene induces a developmental pathway leading to the production of asexual spores. We have introduced mutations into brlA that are expected to disrupt either or both Cys2-His2 Zn(II) coordination sites postulated to exist in the BrlA polypeptide. The resultant brlA alleles fail to induce either the asexual reproductive pathway or the expression of development-specific genes. These data support the hypothesis that brlA encodes a nucleic acid-binding protein whose activity requires each of two zinc fingers.

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页码：1815 / 1817

页数：3

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