Proximal tubular renal dysfunction on treatment with valproic acid

被引：0

作者：

Bettinelli, Alberto ^{[1
]}

Zucca, Claudio ^{[2
]}

Radice, Lucia ^{[2
]}

Stucchi, Sara ^{[1
]}

Tettamanti, Alberto ^{[3
]}

Bianchetti, Mario G. ^{[4
,5
]}

机构：

[1] San Leopoldo Mand Hosp, Dept Pediat, I-23807 Merate, Lecco, Italy

[2] Sci Inst E Medea, Bosisio Parini, Italy

[3] Valduce Hosp, Dept Pediat & Neonatol, Como, Italy

[4] Dept Pediat, Mendrisio, Switzerland

[5] Dept Pediat, Bellinzona, Switzerland

来源：

JOURNAL OF PEDIATRIC NEUROLOGY | 2008年 / 6卷 / 02期

关键词：

Fanconi syndrome; kidney disease; valproic acid; epilepsy;

D O I：

暂无

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A10-year-old severely disabled Italian boy on long-term treatment with valproic acid presented with tubular proteinuria, generalized aminoaciduria, normoglycemic glucosuria, and phosphate wasting. Since no other explanation for these renal tubular abnormalities was found, the treatment with valproic acid was discontinued. The abnormalities resolved within 5 months after discontinuing this anticonvulsant. We recommend screening patients on long-term anticonvulsant therapy with valproate periodically for renal tubular dysfunction, either via urinalysis or via measurement of urinary lactate/creatinine ratio, if clinical suspicion is high.

引用

页码：189 / 190

页数：2

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