PRELABELING OF CHIMERIC MONOCLONAL-ANTIBODY L6 WITH (90)YTTRIUM-1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETIC AND (111)INDIUM-1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETIC ACID (DOTA) CHELATES FOR RADIOIMMUNODIAGNOSIS AND THERAPY

被引：0
|
作者：
LI, M
MEARES, CF
SALAKO, Q
KUKIS, DL
ZHONG, GR
MIERS, L
DENARDO, SJ
机构：
[1] UNIV CALIF DAVIS, DEPT CHEM, DAVIS, CA 95616 USA
[2] UNIV CALIF DAVIS, MED CTR, DEPT INTERNAL MED, SACRAMENTO, CA 95817 USA
来源：
CANCER RESEARCH | 1995年 / 55卷 / 23期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Y-90 and In-111 have been attached to chimeric monoclonal antibody L6 with a bifunctional chelating agent (DOTA-peptide isothiocyanate), The bifunctional chelating agent was prelabeled with either radiometal and then conjugated to the antibody, Studies in human patients showed excellent In-111 single-photon emission computed tomography images of breast cancer lesions 24 h after injection.
引用
收藏
页码：S5726 / S5728
页数：3
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