PRELABELING OF CHIMERIC MONOCLONAL-ANTIBODY L6 WITH (90)YTTRIUM-1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETIC AND (111)INDIUM-1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETIC ACID (DOTA) CHELATES FOR RADIOIMMUNODIAGNOSIS AND THERAPY

被引：0

作者：

LI, M

MEARES, CF

SALAKO, Q

KUKIS, DL

ZHONG, GR

MIERS, L

DENARDO, SJ

机构：

[1] UNIV CALIF DAVIS, DEPT CHEM, DAVIS, CA 95616 USA

[2] UNIV CALIF DAVIS, MED CTR, DEPT INTERNAL MED, SACRAMENTO, CA 95817 USA

来源：

CANCER RESEARCH | 1995年 / 55卷 / 23期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Y-90 and In-111 have been attached to chimeric monoclonal antibody L6 with a bifunctional chelating agent (DOTA-peptide isothiocyanate), The bifunctional chelating agent was prelabeled with either radiometal and then conjugated to the antibody, Studies in human patients showed excellent In-111 single-photon emission computed tomography images of breast cancer lesions 24 h after injection.

引用

页码：S5726 / S5728

页数：3

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