PRELABELING OF CHIMERIC MONOCLONAL-ANTIBODY L6 WITH (90)YTTRIUM-1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETIC AND (111)INDIUM-1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETIC ACID (DOTA) CHELATES FOR RADIOIMMUNODIAGNOSIS AND THERAPY

被引：0
|
作者：
LI, M
MEARES, CF
SALAKO, Q
KUKIS, DL
ZHONG, GR
MIERS, L
DENARDO, SJ
机构：
[1] UNIV CALIF DAVIS, DEPT CHEM, DAVIS, CA 95616 USA
[2] UNIV CALIF DAVIS, MED CTR, DEPT INTERNAL MED, SACRAMENTO, CA 95817 USA
来源：
CANCER RESEARCH | 1995年 / 55卷 / 23期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Y-90 and In-111 have been attached to chimeric monoclonal antibody L6 with a bifunctional chelating agent (DOTA-peptide isothiocyanate), The bifunctional chelating agent was prelabeled with either radiometal and then conjugated to the antibody, Studies in human patients showed excellent In-111 single-photon emission computed tomography images of breast cancer lesions 24 h after injection.
引用
收藏
页码：S5726 / S5728
页数：3
相关论文
共 50 条
  • [1] The synthesis of 2-(p-hydroxyphenyl)methyl-1,4,7,10-tetraazacyclododecane-N,N′, N"N,N′"-tetraacetic acid.
    Galloway, E
    Murphy, C
    Elbert, JE
    Majerle, RS
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 215 : U210 - U210
  • [2] Synthesis and evaluation of novel bifunctional chelating agents based on 1,4,7,10-tetraazacyclododecane-N,N′,N",N′"-tetraacetic acid for radiolabeling proteins
    Chappell, LL
    Ma, D
    Milenic, DE
    Garmestani, K
    Venditto, V
    Beitzel, MP
    Brechbiel, MW
    NUCLEAR MEDICINE AND BIOLOGY, 2003, 30 (06) : 581 - 595
  • [3] Pretargeted α emitting radioimmunotherapy using 213Bi 1,4,7,10-tetraazacyclododecane-N,N′,N",N′"-tetraacetic acid-biotin
    Yao, ZS
    Zhang, ML
    Garmestani, K
    Axworthy, DB
    Mallett, RW
    Fritzberg, AR
    Theodore, LJ
    Plascjak, PS
    Eckelman, WC
    Waldmann, TA
    Pastan, I
    Paik, CH
    Brechbiel, MW
    Carrasquillo, JA
    CLINICAL CANCER RESEARCH, 2004, 10 (09) : 3137 - 3146
  • [4] THERMODYNAMIC STUDY OF LANTHANIDE COMPLEXES OF 1,4,7-TRIAZACYCLONONANE-N,N',N''-TRIACETIC ACID AND 1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETIC ACID
    CACHERIS, WP
    NICKLE, SK
    SHERRY, AD
    INORGANIC CHEMISTRY, 1987, 26 (06) : 958 - 960
  • [5] Total solid-phase synthesis of 1,4,7,10-tetraazacyclododecane-N,N′,N",N′′′-tetraacetic acid-functionalized peptides for radioimmunotherapy
    Peterson, JJ
    Pak, RH
    Meares, CF
    BIOCONJUGATE CHEMISTRY, 1999, 10 (02) : 316 - 320
  • [6] Simplified synthesis of the bifunctional chelating agent 2-(4-aminobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid
    Mishra, AK
    Gestin, JF
    Benoist, E
    FaivreChauvet, A
    Chatal, JF
    NEW JOURNAL OF CHEMISTRY, 1996, 20 (05) : 585 - 588
  • [7] The coordination chemistry of 1,4,7,10-tetraazacyclododecane-N,N′,N",N′′′-tetraacetic acid (H4DOTA): Structural overview and analyses on structure-stability relationships
    Viola-Villegas, Nerissa
    Doyle, Robert P.
    COORDINATION CHEMISTRY REVIEWS, 2009, 253 (13-14) : 1906 - 1925
  • [8] Magnetically targeted delivery of aminobenzyl-1,4,7,10-tetraazacyclododecane-n,n,n,n-tetraacetic acid (ABz-DOTA) chelated 90Y for cancer therapy.
    Li, Y
    Failing, S
    Tapolsky, G
    Yu, J
    Hafeli, U
    JOURNAL OF NUCLEAR MEDICINE, 2002, 43 (05) : 370P - 370P
  • [9] STRUCTURES OF THE YTTRIUM COMPLEXES OF 1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETIC ACID (H-4 DOTA) AND N,N''-BIS(BENZYLCARBAMOYLMETHYL)DIETHYLENE-TRIAMINE-N,N',N''-TRIACETIC ACID AND THE SOLUTION STRUCTURE OF A ZIRCONIUM COMPLEX OF H-4 DOTA
    PARKER, D
    PULUKKODY, K
    SMITH, FC
    BATSANOV, A
    HOWARD, JAK
    JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1994, (05): : 689 - 693
  • [10] Microwave-assisted rapid synthesis of 166Ho-1,4,7,10-tetraazacyclododecane-N,N′,N",N′"-tetraacetic acid:: A bifunctional chelating agent for radiopharmaceuticals
    Park, Sang Hyun
    Gwon, Hui Jeong
    Jang, Seung Ho
    ASIAN JOURNAL OF CHEMISTRY, 2007, 19 (01) : 391 - 395
12345