ANALYSIS OF THE HUNTINGTIN GENE REVEALS A TRINUCLEOTIDE-LENGTH POLYMORPHISM IN THE REGION OF THE GENE THAT CONTAINS 2 CCG-RICH STRETCHES AND A CORRELATION BETWEEN DECREASED AGE-OF-ONSET OF HUNTINGTONS-DISEASE AND CAG REPEAT NUMBER

被引：113
作者：
RUBINSZTEIN, DC
BARTON, DE
DAVISON, BCC
FERGUSONSMITH, MA
机构：
[1] East Anglian Regional Genetics Service Molecular Genetics Laboratory, Addenbrooke's NHS Trust, Cambridge CB2 2QQ, Hills Road
来源：
HUMAN MOLECULAR GENETICS | 1993年 / 2卷 / 10期
关键词：
D O I：
10.1093/hmg/2.10.1713
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：1713 / 1715
页数：3
相关论文
共 5 条
[1]  
HARPER PS, 1991, HUNTINGTONS DISEASE, P251
[2]   A NOVEL GENE CONTAINING A TRINUCLEOTIDE REPEAT THAT IS EXPANDED AND UNSTABLE ON HUNTINGTONS-DISEASE CHROMOSOMES [J].
MACDONALD, ME ;
AMBROSE, CM ;
DUYAO, MP ;
MYERS, RH ;
LIN, C ;
SRINIDHI, L ;
BARNES, G ;
TAYLOR, SA ;
JAMES, M ;
GROOT, N ;
MACFARLANE, H ;
JENKINS, B ;
ANDERSON, MA ;
WEXLER, NS ;
GUSELLA, JF ;
BATES, GP ;
BAXENDALE, S ;
HUMMERICH, H ;
KIRBY, S ;
NORTH, M ;
YOUNGMAN, S ;
MOTT, R ;
ZEHETNER, G ;
SEDLACEK, Z ;
POUSTKA, A ;
FRISCHAUF, AM ;
LEHRACH, H ;
BUCKLER, AJ ;
CHURCH, D ;
DOUCETTESTAMM, L ;
ODONOVAN, MC ;
RIBARAMIREZ, L ;
SHAH, M ;
STANTON, VP ;
STROBEL, SA ;
DRATHS, KM ;
WALES, JL ;
DERVAN, P ;
HOUSMAN, DE ;
ALTHERR, M ;
SHIANG, R ;
THOMPSON, L ;
FIELDER, T ;
WASMUTH, JJ ;
TAGLE, D ;
VALDES, J ;
ELMER, L ;
ALLARD, M ;
CASTILLA, L ;
SWAROOP, M .
CELL, 1993, 72 (06) :971-983
[3]   ISOLATION AND NUCLEOTIDE-SEQUENCE OF THE GENE ENCODING HUMAN RHODOPSIN [J].
NATHANS, J ;
HOGNESS, DS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (15) :4851-4855
[4]  
QUARREL O, 1991, HUNTINGTONS DISEASE, P37
[5]   A NEW POLYMERASE CHAIN-REACTION (PCR) ASSAY FOR THE TRINUCLEOTIDE REPEAT THAT IS UNSTABLE AND EXPANDED ON HUNTINGTONS-DISEASE CHROMOSOMES [J].
WARNER, JP ;
BARRON, LH ;
BROCK, DJH .
MOLECULAR AND CELLULAR PROBES, 1993, 7 (03) :235-239
1