STIMULATION OF NERVE GROWTH-FACTOR PRODUCTION BY PYRROLOQUINOLINE QUINONE AND ITS DERIVATIVES IN-VITRO AND IN-VIVO

被引：61
作者：
YAMAGUCHI, K
SASANO, A
URAKAMI, T
TSUJI, T
KONDO, K
机构：
[1] SAGAMI CHEM RES CTR, SAGAMIHARA, KANAGAWA 229, JAPAN
[2] MISTUBISHI GAS CHEM CO LTD, DIV BIOCHEM, MINATO KU, TOKYO 105, JAPAN
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1993年 / 57卷 / 07期
关键词：
D O I：
10.1271/bbb.57.1231
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pyrroloquinoline quinone (PQQ), which is a cofactor of microbial quinoprotein enzymes, was found to be a potent enhancer of nerve growth factor (NGF) production in vitro. One of PQQ derivatives, oxazopyrroloquinoline trimethylester, had little activity in vitro, but increased the NGF content in rat brain in vivo.
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页码：1231 / 1233
页数：3
相关论文
共 21 条
[1]  
ADACHI O, 1991, NIPPON NOGEIKAGAKU K, V65, P377
[2]   QUINOPROTEINS - ENZYMES CONTAINING THE QUINONOID COFACTOR PYRROLOQUINOLINE QUINONE, TOPAQUINONE OR TRYPTOPHAN-TRYPTOPHAN QUINONE [J].
DUINE, JA .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 200 (02) :271-284
[3]   AMELIORATION OF CHOLINERGIC NEURON ATROPHY AND SPATIAL MEMORY IMPAIRMENT IN AGED RATS BY NERVE GROWTH-FACTOR [J].
FISCHER, W ;
WICTORIN, K ;
BJORKLUND, A ;
WILLIAMS, LR ;
VARON, S ;
GAGE, FH .
NATURE, 1987, 329 (6134) :65-68
[4]  
FURUKAWA S, 1991, KAGAKU TO SEIBUTU, V29, P640
[5]  
FURUKAWA Y, 1986, J BIOL CHEM, V261, P6039
[6]  
FURUKAWA Y, 1986, FEBS LETT, V208, P2558
[7]  
HAMAGISHI Y, 1990, J PHARMACOL EXP THER, V255, P980
[8]  
HEFTI F, 1986, J NEUROSCI, V6, P2155
[9]   CHRONIC ADMINISTRATION OF NERVE GROWTH-FACTOR AND OTHER NEUROTROPHIC FACTORS TO THE BRAIN [J].
HEFTI, F ;
KNUSEL, B .
NEUROBIOLOGY OF AGING, 1988, 9 (5-6) :689-690
[10]  
HEPLER DJ, 1985, J NEUROSCI, V5, P866
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