COMPARATIVE METABOLISM OF PHENANTHRENE IN THE RAT AND GUINEA-PIG

被引：14
|
作者：
CHU, I [1 ]
NG, KME [1 ]
BENOIT, FM [1 ]
MOIR, D [1 ]
机构：
[1] BUR CHEM HAZARDS,ENVIRONM HLTH DIRECTORATE,DIV MONITORING & CRITERIA,OTTAWA K1A 0L2,ONTARIO,CANADA
来源：
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES | 1992年 / 27卷 / 06期
关键词：
PHENANTHRENE; COMPARATIVE METABOLISM;
D O I：
10.1080/03601239209372809
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
In the present study the biotransformation of phenanthrene in the rat and guinea pig was investigated. C-14-labelled phenanthrene was administered by gavage in corn oil to Sprague-Dawley rats (10 mg/kg b.w./day) and guinea pigs (10 mg/kg b.w./day). Urine and feces were separately collected for the determination of the radioactivity content, and pooled urine was used for the analysis of metabolites. Phenanthrene was metabolized by the rat and guinea pig to free hydroxylated phenanthrenes and their conjugates. The percentages of conjugates, expressed as the total urinary radioactivity, were 39% glucuronides, 24% sulfates and 18% cysteinylglycine for rats; and 39% glucuronides, 23% sulfates and 28% cysteinylglycine for guinea pigs. Enzymatic hydrolysis of glucuronides and sulfates resulted in the formation of free 1,2-, 3,4- and 9,10-dihydrodiols of phenanthrene and 1-, 2-, 3-, and 4-hydroxyphenanthrene in both species.
引用
收藏
页码：729 / 749
页数：21
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