SOMATOSTATIN RECEPTOR IMAGING - INVIVO LOCALIZATION OF TUMORS WITH A RADIOLABELED SOMATOSTATIN ANALOG

被引：29

作者：

LAMBERTS, SWJ ^{[1
]}

BAKKER, WH ^{[1
]}

REUBI, JC ^{[1
]}

KRENNING, EP ^{[1
]}

机构：

[1] SANDOZ LTD,RES INST,BERN,SWITZERLAND

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1990年 / 37卷 / 06期

关键词：

D O I：

10.1016/0960-0760(90)90469-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper presents the results of the visualization of somatostatin (SS) receptor positive tumors in man after the i.v. administration of the SS analog Tyr3-octreotide coupled to I-123. It is an easy, quick and harmless procedure which allows imaging of primary and (often unexpected) secondary deposits and/or multiple localizations of the majority of endocrine pancreatic tumors, metastatic carcinoids and pituitary tumors, as well as of a multitude of tumors with neuroendocrine characteristics and well-differentiated brain tumors and meningiomas. In the case of hormone-secreting tumors a positive scan in most instances also predicts the subsequent successful therapy with octreotide.

引用

页码：1079 / 1082

页数：4

共 15 条

[1] PEPTIDES IN BRAIN - NEW ENDOCRINOLOGY OF NEURON [J].