LARGE ANAPLASTIC CELL KI-1 POSITIVE MALIGNANT-LYMPHOMA WITH PECULIAR ENDOCYTOTIC VACUOLES

被引：11
作者：
LETOURNEAU, A
AUDOUIN, J
DIEBOLD, J
PUJADELAURAINE, E
BERNADOU, A
机构：
[1] HOP HOTEL DIEU,SERV CENT JACQUES DELARUE ANAT & CYTOL PATHOL,F-75181 PARIS 04,FRANCE
[2] HOP HOTEL DIEU,SERV ONCOL & MED INTERNE,F-75181 PARIS 04,FRANCE
来源：
PATHOLOGY RESEARCH AND PRACTICE | 1990年 / 186卷 / 06期
关键词：
LARGE ANAPLASTIC CELL LYMPHOMA; KI-1 POSITIVE LYMPHOMA; T-LYMPHOMA; LYMPHOMA WITH CYTOPLASMIC INCLUSIONS; ENDOCYTOTIC VACUOLES;
D O I：
10.1016/S0344-0338(11)80270-0
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Unusual intracytoplasmic inclusions are occasionally seen in some variants of malignant lymphoma. We report here a case of large anaplastic cell malignant lymphoma with peculiar vacuoles of probable endocytotic origin. Immunological findings demonstrated the characteristics of activated cells typical of a large anaplastic cell Ki-1 positive lymphoma. The tumour cells exhibited a phenotype of peripheral helper-inducer T-cells. The intracytoplasmic vacuoles were positive with the T surface marker antibodies. Ultrastructurally, these inclusions were closely related to the microvesicle-containing vacuoles reported in signet ring cell lymphomas of B or T cell lineage. The mechanism of cytoplasmic vacuole formation is discussed. An endocytotic origin is possible. The resemblance to the "capping" phenomenon in small lymphocytes is stressed.
引用
收藏
页码：784 / 792
页数：9
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