HDL-CHOLESTEROL INCREASE ASSOCIATED TO TRIGLYCERIDES DEGRADATION IN-VITRO

The effect of muscle tissue from rats trained by swimming on the extracellular degradation of triglyceride (TG) rich particles has been studied in vitro. During incubation, there is a progressive decline of the TG concentration in the incubation medium. At the end of the incubation period (90 min), a significantly reduction in the TG levels (p < 0.05) is associated with a significant increase in the high-density lipoprotein (HDL) cholesterol level (p < 0.005). There are no significant changes in total cholesterol levels. The correlation of the TG decline with the HDL-cholesterol increase is significant (r = 0.695, p < 0.05, n = 25). The experimental model used here could be of great interest for the in vitro study of factors affecting lipid levels in plasma.