HORMONE SENSITIVITY IN BREAST-CANCER - INFLUENCE OF HETEROGENEITY OF ESTROGEN-RECEPTOR EXPRESSION AND CELL-PROLIFERATION

被引：63

作者：

NICHOLSON, RI ^{[1
]}

BOUZUBAR, N ^{[1
]}

WALKER, KJ ^{[1
]}

MCCLELLAND, R ^{[1
]}

DIXON, AR ^{[1
]}

ROBERTSON, JFR ^{[1
]}

ELLIS, IO ^{[1
]}

BLAMEY, RW ^{[1
]}

机构：

[1] CITY HOSP NOTTINGHAM,NOTTINGHAM NG5 1PB,ENGLAND

来源：

EUROPEAN JOURNAL OF CANCER | 1991年 / 27卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0277-5379(91)90145-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The percentage of oestrogen receptor (ER) positive cells in a series of 118 breast cancers has been examined by immunohistochemistry in relation to patients' response to endocrine therapy. Positive and negative predictive values have been used to calculate appropriate cut-off points. The rate of response to treatment was significantly higher in women with receptor positive tumours, especially where the tumours contained more than 70% positive cells. Tumours that were apparently negative for ER expression rarely responded to endocrine therapy. The hormone sensitivity of ER positive breast cancer was also influenced by the rate of tumour cell proliferation, with tumours expressing high levels of Ki67 immunostaining rarely responding to therapy.

引用

页码：908 / 913

页数：6

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