SPATIAL-LEARNING IMPAIRMENT IN MICE INFECTED WITH LEGIONELLA-PNEUMOPHILA OR ADMINISTERED EXOGENOUS INTERLEUKIN-1-BETA

被引：163

作者：

GIBERTINI, M ^{[1
]}

NEWTON, C ^{[1
]}

FRIEDMAN, H ^{[1
]}

KLEIN, TW ^{[1
]}

机构：

[1] UNIV S FLORIDA,DEPT MED MICROBIOL & IMMUNOL,TAMPA,FL 33620

来源：

BRAIN BEHAVIOR AND IMMUNITY | 1995年 / 9卷 / 02期

关键词：

D O I：

10.1006/brbi.1995.1012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of interleukin-1 beta (IL1 beta) on spatial learning was examined: In one experiment, C57BL/6 mice were given daily injections (100 ng/mouse) of recombinant murine IL1 beta prior to training on the Morris water maze. In another experiment, mice were infected with a sublethal dose of a gram-negative bacterium (Legionella pneumophila; Lp). Mice rendered ill by the infection were given either anti-IL1 beta antibodies (100 mu g/mouse) or saline and then trained on the water maze. Results indicated that (1) exogenous IL1 beta blocked acquisition of spatial learning, (2) Lp infection attenuated learning on this task, and (3) neutralizing circulating IL1 beta in Lp-infected mice normalized learning despite the continuation of the illness. The data indicate that cognitive impairment may be a component of cytokine-mediated sickness behavior. (C) 1995 Academic Press, inc.

引用

页码：113 / 128

页数：16

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