SPECTROFLUORIMETRIC DETERMINATION OF 3 PHARMACEUTICAL THIOCOMPOUNDS AND ALLOPURINOL USING MERCUROCHROME

被引：22
作者：
BEDAIR, MM
KORANY, MA
ELSAYED, MA
FAHMY, OT
机构：
[1] Department of Pharmaceutical analytically Chemistry, Faculty of Pharmacy, University of Alexandria Alexandria
来源：
SPECTROSCOPY LETTERS | 1990年 / 23卷 / 02期
关键词：
Allopurinol; Carbimazole; Cimetidine; Fluorimetry; Mercurochrome; Pharmaceutical preparations; Thiabendazole;
D O I：
10.1080/00387019008054044
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
A new, simple and sensitive fluorimetric method for the determination of three pharmaceutical thiocompounds: cimetidine, thiabendazole and carbimazole, and also allopurinol, has been presented. The method is based on the fluorescence quenching of mercurochrome (MER) in an aqueous alkaline medium. Calibration graphs correlating the fluorescence difference (Fo-F) or the fluoresence ratio (Fo/F) of MER before (Fo) and after (F) quencher addition versus the concentration of the latter are linear. Such linearity permitted the successful application of. © 1990, Taylor & Francis Group, LLC. All rights reserved.
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页码：161 / 173
页数：13
相关论文
共 28 条
[1]  
BAVIN PMG, 1984, ANAL PROFILES DRUG S, V13, P168
[2]  
CLARKE EGC, 1974, ISOLATION IDENTIFICA, P569
[3]   DIRECT ELECTROCHEMICAL METHOD FOR DETERMINATION OF ALLOPURINOL AND URIC-ACID MIXTURES - ADSORPTION OF URIC-ACID AT PYROLYTIC-GRAPHITE ELECTRODE [J].
DRYHURST, G ;
DE, PK .
ANALYTICA CHIMICA ACTA, 1972, 58 (01) :183-&
[4]  
GUVEN KC, 1982, ECZACITIC B, V24, P30
[5]   SPECTROPHOTOMETRIC DETERMINATION OF SOME ANTIINFLAMMATORY AGENTS USING N-BROMOSUCCINIMIDE [J].
HASSIB, ST ;
SAFWAT, HM ;
ELBAGRY, RI .
ANALYST, 1986, 111 (01) :45-48
[6]  
KAC M, 1983, ANAL CHEM S SER, P71
[7]   STUDIES ON THE CHEMICALS USED IN HOUSEHOLD NECESSITIES .1. ANALYSIS OF ANTIMICROBIAL AGENTS IN FABRICS [J].
KANETOSHI, A ;
OGAWA, H ;
ANETAI, M ;
KATSURA, E ;
KANESHIMA, H .
EISEI KAGAKU-JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1985, 31 (04) :245-250
[8]  
KORANY MA, UNPUB SPECTROSCOPY L
[9]  
KRISHNAN M V S, 1986, Indian Drugs, V23, P469
[10]  
Lakowicz JR, 1983, PRINCIPLES FLUORESCE, P260
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