BIO-SPECKLE PHENOMENA AND THEIR APPLICATION TO THE EVALUATION OF BLOOD-FLOW

The study of time-varying speckle phenomena observed in light-fields scattered from living objects is reviewed. The laser speckles produced from living objects may be called 'bio-speckles' and fluctuate temporally due to various physiological movements such as blood flow. The time-varying properties of the bio-speckles are experimentally investigated from the analyses of the power spectrum and the autocorrelation function. Based on the knowledge of dynamic bio-speckles, some methods are introduced for evaluating blood flow in the skin surface, internal organs, and ocular fundus. The experimental results show that the degree of blood flow is reflected sensitively by the time-varying properties of the bio-speckles and this can be utilized for monitoring the blood flow.