Pretransplant Fasting Glucose Predicts New-Onset Diabetes after Liver Transplantation

被引：28

作者：

Carey, Elizabeth J. ^{[1
]}

Aqel, Bashar A. ^{[1
]}

Byrne, Thomas J. ^{[1
]}

Douglas, David D. ^{[1
]}

Rakela, Jorge ^{[1
]}

Vargas, Hugo E. ^{[1
]}

Moss, Adyr A. ^{[2
]}

Mulligan, David C. ^{[2
]}

Reddy, K. Sudhakar ^{[2
]}

Chakkera, Harini A. ^{[3
]}

机构：

[1] Mayo Clin Arizona, Div Hepatol, 5777 Mayo Blvd, Phoenix, AZ 85054 USA

[2] Mayo Clin Arizona, Div Transplant Surg, Phoenix, AZ 85054 USA

[3] Mayo Clin Arizona, Div Nephrol, Phoenix, AZ 85054 USA

来源：

JOURNAL OF TRANSPLANTATION | 2012年 / 2012卷

关键词：

D O I：

10.1155/2012/614781

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

New-onset diabetes after transplantation (NODAT) is common after liver transplant and associated with poorer outcomes. The aim of this study was to identify risk factors for NODAT in liver transplant recipients off corticosteroids. In 225 adult nondiabetic liver transplant recipients, the mean age was 51.7 years, the majority were men (71%), and half had HCV (49%). The mean calculated MELD score at transplantation was 18.7, and 19% underwent living-donor transplant (LDLT). One year after transplantation, 17% developed NODAT, and an additional 16% had impaired fasting glucose. The incidence of NODAT in patients with HCV was 26%. In multivariate analysis, HCV, pretransplant FPG, and LDLT were significant. Each 10 mg/dL increase in pretransplant FPG was associated with a twofold increase in future development of NODAT. The incidence of NODAT after liver transplant in patients off corticosteroids is 17%. Risk factors for developing NODAT include HCV and pretransplant FPG; LDLT is protective.

引用

页数：6

共 20 条

[1] Diagnosis and Classification of Diabetes Mellitus [J].

DIABETES CARE, 2010, 33 :S62-S69

[2] Posttransplant diabetes mellitus in liver transplant recipients: Risk factors, temporal relationship with hepatitis C virus allograft hepatitis, and impact on mortality [J].

Baid, S ;

Cosimi, AB ;

Farrell, ML ;

Schoenfeld, DA ;

Feng, S ;

Chung, RT ;

Tolkoff-Rubin, N ;

Pascual, M .

TRANSPLANTATION, 2001, 72 (06) :1066-1072

[3]

Chakkera H, 2010, AM J TRANSPLANT, V10, P243

[4]

Harrison SA, 2006, HEPATOLOGY, V43, P1168, DOI 10.1002/hep.21125

[5] New onset diabetes mellitus in patients receiving calcineurin inhibitors: A systematic review and meta-analysis [J].

Heisel, O ;

Heisel, R ;

Balshaw, R ;

Keown, P .

AMERICAN JOURNAL OF TRANSPLANTATION, 2004, 4 (04) :583-595

[6] Outcome of patients with new-onset diabetes mellitus after liver transplantation compared with those without diabetes mellitus [J].

John, PR ;

Thuluvath, PJ .

LIVER TRANSPLANTATION, 2002, 8 (08) :708-713

[7] Risk Factors for New-Onset Diabetes Mellitus in Adult Liver Transplant Recipients, an Analysis of the Organ Procurement and Transplant Network/United Network for Organ Sharing Database [J].

Kuo, Hung-Tien ;

Sampaio, Marcelo Santos ;

Ye, Xiaoyi ;

Reddy, Pavani ;

Martin, Paul ;

Bunnapradist, Suphamai .

TRANSPLANTATION, 2010, 89 (09) :1134-1140

[8] New-onset diabetes after liver transplantation: From pathogenesis to management [J].

Marchetti, P .

LIVER TRANSPLANTATION, 2005, 11 (06) :612-620

[9] Long-term Management of the Liver Transplant Patient: Recommendations for the Primary Care Doctor [J].

McGuire, B. M. ;

Rosenthal, P. ;

Brown, C. C. ;

Busch, A. M. H. ;

Calcatera, S. M. ;

Claria, R. S. ;

Hunt, N. K. ;

Korenblat, K. M. ;

Mazariegos, G. V. ;

Moonka, D. ;

Orloff, S. L. ;

Perry, D. K. ;

Rosen, C. B. ;

Scott, D. L. ;

Sudan, D. L. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2009, 9 (09) :1988-2003

[10] Negative impact of new-onset diabetes mellitus on patient and graft survival after liver transplantation: Long-term follow up [J].

Moon, Jang I. ;

Barbeito, Ralph ;

Faradji, Raquel N. ;

Gaynor, Jeffrey J. ;

Tzakis, Andreas G. .

TRANSPLANTATION, 2006, 82 (12) :1625-1628

← 1 2 →