MOLECULAR-CLONING AND IDENTIFICATION OF 2 TYPES OF HAMSTER CYCLIN-DEPENDENT KINASES - CDK2 AND CDK2L

被引：18

作者：

NOGUCHI, E ^{[1
]}

SEKIGUCHI, T ^{[1
]}

YAMASHITA, K ^{[1
]}

NISHIMOTO, T ^{[1
]}

机构：

[1] KYUSHU UNIV,GRAD SCH MED SCI,DEPT MOLEC BIOL,FUKUOKA 812,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 197卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.2650

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We isolated two types of hamster cyclin-dependent kinase 2 (cdk2) cDNAs from BHK21 cells derived from Golden hamsters. One type of cdk2 (cdk2hm) encodes the 32 kDa protein consisting of 298 predicted amino acids and shows strong homology to the cdk2 cDNAs of humans and Xenopus. The other cdk2 (cdk2Lhm) encodes the 38 kDa protein containing the insertion of 48 amino acids in the cdk2hm protein. Immunoblotting analysis suggested that these two types of cdk2 protein exist in mammalian cells. The cdk2hm has the activity of protein kinase, while the cdk2Lhm does not, however, both bind with cyclin E. © 1993 Academic Press, Inc.

引用

页码：1524 / 1529

页数：6

共 50 条

[1] Activation of cyclin-dependent kinases CDC2 and CDK2 in hepatocellular carcinoma
Li, KKW
Ng, IOL
Fan, ST
Albrecht, JH
Yamashita, K
Poon, RYC
LIVER, 2002, 22 (03): : 259 - 268
[2] A specific inhibitor of cyclin-dependent protein kinases, CDC2 and CDK2
Park, SG
Cheon, JY
Lee, YH
Park, JS
Lee, KY
Lee, CH
Lee, SK
MOLECULES AND CELLS, 1996, 6 (06) : 679 - 683
[3] The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism
Clare, PM
Poorman, RA
Kelley, LC
Watenpaugh, KD
Bannow, CA
Leach, KL
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (51) : 48292 - 48299
[4] The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis
Hakem, A
Sasaki, T
Kozieradzki, I
Penninger, JM
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (06): : 957 - 967
[5] A comprehensive bioinformatic analysis of cyclin-dependent kinase 2 (CDK2) in glioma
Liu, Hengrui
Weng, Jieling
GENE, 2022, 822
[6] Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5
Meijer, L.
Borgne, A.
Mulner, O.
Chong, J. P. J.
European Journal of Biochemistry, 243 (1-2):
[7] Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5
Meijer, L
Borgne, A
Mulner, O
Chong, JPJ
Blow, JJ
Inagaki, N
Inagaki, M
Delcros, JG
Moulinoux, JP
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 243 (1-2): : 527 - 536
[8] ABNORMAL ALZHEIMER-LIKE PHOSPHORYLATION OF TAU-PROTEIN BY CYCLIN-DEPENDENT KINASES CDK2 AND CDK5
BAUMANN, K
MANDELKOW, EM
BIERNAT, J
PIWNICAWORMS, H
MANDELKOW, E
FEBS LETTERS, 1993, 336 (03): : 417 - 424
[9] Transforming growth factor β targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity
Nagahara, H
Ezhevsky, SA
Vocero-Akbani, AM
Kaldis, P
Solomon, MJ
Dowdy, SF
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) : 14961 - 14966
[10] Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells
Matsumoto, Y
Hayashi, K
Nishida, E
CURRENT BIOLOGY, 1999, 9 (08) : 429 - 432

← 1 2 3 4 5 →