REGULATION OF IL-6 RECEPTOR AND GP130 EXPRESSION ON HUMAN CELL-LINES OF LYMPHOID AND MYELOID ORIGIN

被引：11

作者：

FALUS, A ^{[1
]}

TAGA, T ^{[1
]}

HIBI, M ^{[1
]}

MURAKAMI, M ^{[1
]}

KISHIMOTO, T ^{[1
]}

机构：

[1] OSAKA UNIV,INST MOLEC & CELLULAR BIOL,DEPT IMMUNOL,OSAKA,JAPAN

来源：

CYTOKINE | 1992年 / 4卷 / 06期

关键词：

D O I：

10.1016/1043-4666(92)90010-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression of 80 kDa interleukin-6 receptor (IL-6R) and the associated molecule gp130 has been studied on human cell lines by FACS- and Northern blot analysis. The effects of dexamethasone, dibutyric-(DB)-cAMP and phorbol-12-myristate-13-acetate (TPA) have been studied on plasmacytoma cell line U266, B cell line BMNH and monocytoid cell line U937. Our data show a definite downregulation of IL-6R and gp130 expression by TPA in U266 and BMNH at both mRNA and cell surface protein levels. In U937 TPA inhibits only the IL-6R expression, without affecting that of gp130. DB-cAMP decreases the expression of both proteins in U937, slightly inhibits the IL-6R expression in U266, but is uneffective in BMNH. Dexamethasone induces considerable upregulation of gp130 only in U266. Our findings suggest separate regulation of IL-6R and gp130 on U266, BMNH and U937 cell lines. © 1992.

引用

页码：495 / 499

页数：5

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