FOLLICULAR DENDRITIC CELLS AND HUMAN-IMMUNODEFICIENCY-VIRUS INFECTIVITY

被引：255

作者：

HEATH, SL

TEW, JG

SZAKAL, AK

BURTON, GF

机构：

[1] VIRGINIA COMMONWEALTH UNIV, DEPT MICROBIOL & IMMUNOL, DIV IMMUNOBIOL, RICHMOND, VA 23298 USA

[2] VIRGINIA COMMONWEALTH UNIV, DEPT ANAT, RICHMOND, VA 23298 USA

来源：

NATURE | 1995年 / 377卷 / 6551期

关键词：

D O I：

10.1038/377740a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

LARGE amounts of human immunodeficiency virus (HIV) localize on follicular dendritic cells (FDC) in the follicles of secondary lymploid tissues following viral infection(1,2). During clinical latency, active viral infection occurs primarily at these sites(3,4). As HIV on FDC is in the form of immune complexes(5), some of which may be formed with neutralizing antibody, we investigated whether HIV on FDC is infectious. We report here that HIV on FDC is highly infectious. Furthermore, FDC can convert neutralized HIV into an infectious form even in the presence of a vast excess of neutralizing antibody. Thus FDC may provide a mechanism whereby HIV infection can continue in the presence of neutralizing antibody.

引用

页码：740 / 744

页数：5

共 29 条

[1] GENITAL HUMAN PAPILLOMAVIRUS INFECTION IN FEMALE UNIVERSITY-STUDENTS AS DETERMINED BY A PCR-BASED METHOD [J].