REGULATION OF THE MEVALONATE PATHWAY

被引：4785
作者：
GOLDSTEIN, JL [1 ]
BROWN, MS [1 ]
机构：
[1] UNIV TEXAS, SW MED CTR, DEPT INTERNAL MED, DALLAS, TX 75235 USA
来源：
NATURE | 1990年 / 343卷 / 6257期
关键词：
D O I：
10.1038/343425a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease. © 1990 Nature Publishing Group.
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页码：425 / 430
页数：6
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