POTENTIAL MULTIFUNCTIONAL ANTICANCER METAL-COMPLEXES .2. SYNTHESIS OF SOME RHODIUM(II) AND PLATINUM(II) COMPLEXES OF DIAMINE-SUBSTITUTED ACRIDINE-4-CARBOXAMIDES, AND THE X-RAY STRUCTURE OF [RH(CH3CO2)2N-[2-(DIMETHYLAMINO)HEXYL]ACRIDINE-4-CARBOXAMIDE]2

The preparations are reported of [Rh(RCO2)2L]2 (where R=CH3, C2H5, and CH3OCH2; L is one of a series of N-[2-(dimethylamino)alkyl]acridine-4-carboxamide ligands in which the alkyl group is ethyl, n-butyl, or n-hexyl) and also the compounds (LH)2PtCl4. X-ray structural studies have been carried out on {Rh(CH3CO2)2[N-(2-dimethylamino)hexyl]acridine-4-carboxamide}2 (1). Compound 1 is triclinic, space group P1, with a=8.149(1), b=8.494(2), c=37.647(10) Å, α=92.49(2), β=95.45(2), γ=91.26(2)°, V=2591 Å3, Z=4 (two crystallographically independent molecules). The acridine-4-carboxamide binds to the dinuclear rhodium(II) acetate unit via the N(CH3)2 nitrogen atom with RhN bond distances of 2.339(6) and 2.349(5) Å, respectively for the two crystallographically independent molecules. In common with the analogous complex formed by 6-chloro-9-(2-dimethylaminoethyl)amino-2-methoxyacridine (D M.L. Goodgame, C.J. Page and D.J. Williams, Inorg. Chim. Acta, 153 (1988) 219), the acridine units form a continuous stack in the crystal, though with different overlapping orientations. In 1 the significantly longer diamine side chain distances the acridine nitrogen atom N(10) c. 11 Å from the nearest rhodium atom. © 1990.