MS-8209, A NEW AMPHOTERICIN-B DERIVATIVE, PROVIDES ENHANCED EFFICACY IN DELAYING HAMSTER SCRAPIE

被引：49

作者：

ADJOU, KT ^{[1
]}

DEMAIMAY, R ^{[1
]}

LASMEZAS, C ^{[1
]}

DESLYS, JP ^{[1
]}

SEMAN, M ^{[1
]}

DORMONT, D ^{[1
]}

机构：

[1] UNIV PARIS 07,IMMUNODIFFERENCIAT LAB,PARIS,FRANCE

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 12期

关键词：

D O I：

10.1128/AAC.39.12.2810

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To test the efficacy of a new amphotericin B derivative, MS-8209, in delaying scrapie, hamsters were infected intracerebrally with the 263K scrapie agent and treated,vith MS-8209 either early in the course of the disease or continuously, The results show that (i) all treatments lengthened the incubation period of hamster scrapie, (ii) continuous treatment with MS-8209 doubled the length of the incubation period compared with that observed in infected, untreated animals, and (iii) all treatments delayed the accumulation of a proteinase-resistant prion protein and glial fibrillary acidic protein in the brain, These findings suggest that MS-8209 is a powerful tool for investigating the pathogenesis of transmissible subacute spongiform encephalopathies.

引用

页码：2810 / 2812

页数：3

共 15 条

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