INTRAUTERINE PARVOVIRUS-B19 INFECTION MAY CAUSE AN ASYMPTOMATIC OR RECURRENT POSTNATAL INFECTION

被引:28
作者
KOCH, WC [1 ]
ADLER, SP [1 ]
HARGER, J [1 ]
机构
[1] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,CHILDRENS MED CTR,DEPT PEDIAT,DIV INFECT DIS,RICHMOND,VA 23298
关键词
HUMAN PARVOVIRUS-B19; PREGNANCY; CONGENITAL INFECTION; POLYMERASE CHAIN REACTION; DIAGNOSIS;
D O I
10.1097/00006454-199309000-00009
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Although infection with parvovirus B19 (B 19) during pregnancy may cause fetal demise, the true incidence of intrauterine infection is unknown. For 19 women with serologically confirmed B19 infections between 4 and 38 weeks of gestation, we performed follow-up examinations of their infants. Serial sonograms of the 19 fetuses showed that none developed hydrops. All 19 women delivered healthy term infants. Cord sera of four infants were tested for IgM to B19 and three were positive. Between 3 and 21 months of age, all 19 infants had normal physical examinations, developmental evaluations and hematocrits; and 16 lacked IgG to B19. One infant who was IgM-positive to B19 at birth was IgM-positive at age 7 months when he also had an IgG titer to B19 of 1:500 000 (mother's concurrent titer, 1:10 000), and had B19 DNA in serum detected by polymerase chain reaction. The other two infants who were IgM-positive at birth were IgM- and IgG-negative by 11 and 16 months of age. These results suggest that intrauterine B19 infection may be frequent and occasionally cause an asymptomatic postnatal infection.
引用
收藏
页码:747 / 750
页数:4
相关论文
共 29 条
[1]   HUMAN PARVOVIRUS INFECTION IN PREGNANCY AND HYDROPS-FETALIS [J].
ANAND, A ;
GRAY, ES ;
BROWN, T ;
CLEWLEY, JP ;
COHEN, BJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1987, 316 (04) :183-186
[2]   DETECTION OF ANTIBODIES AND ANTIGENS OF HUMAN PARVOVIRUS B19 BY ENZYME-LINKED-IMMUNOSORBENT-ASSAY [J].
ANDERSON, LJ ;
TSOU, C ;
PARKER, RA ;
CHORBA, TL ;
WULFF, H ;
TATTERSALL, P ;
MORTIMER, PP .
JOURNAL OF CLINICAL MICROBIOLOGY, 1986, 24 (04) :522-526
[3]  
ANDERSON MJ, 1983, LANCET, V1, P1378
[4]   EXPERIMENTAL PARVOVIRAL INFECTION IN HUMANS [J].
ANDERSON, MJ ;
HIGGINS, PG ;
DAVIS, LR ;
WILLMAN, JS ;
JONES, SE ;
KIDD, IM ;
PATTISON, JR ;
TYRRELL, DAJ .
JOURNAL OF INFECTIOUS DISEASES, 1985, 152 (02) :257-265
[5]  
[Anonymous], 1990, BRIT MED J, V300, P1166
[6]  
BOND PR, 1986, LANCET, V1, P448
[7]   INFECTION WITH PARVOVIRUS DURING PREGNANCY [J].
BROWN, T ;
RITCHIE, LD .
BRITISH MEDICAL JOURNAL, 1985, 290 (6467) :559-560
[8]  
BROWN T, 1984, LANCET, V2, P1033
[9]   THE ROLE OF PARVOVIRUS-B19 IN APLASTIC CRISIS AND ERYTHEMA INFECTIOSUM (5TH DISEASE) [J].
CHORBA, T ;
COCCIA, P ;
HOLMAN, RC ;
TATTERSALL, P ;
ANDERSON, LJ ;
SUDMAN, J ;
YOUNG, NS ;
KURCZYNSKI, E ;
SAARINEN, UM ;
MOIR, R ;
LAWRENCE, DN ;
JASON, JM ;
EVATT, B .
JOURNAL OF INFECTIOUS DISEASES, 1986, 154 (03) :383-393
[10]   CHRONIC PARVOVIRUS INFECTION IN A PRESUMABLY IMMUNOLOGICALLY HEALTHY WOMAN [J].
FADEN, H ;
GARY, GW ;
ANDERSON, LJ .
CLINICAL INFECTIOUS DISEASES, 1992, 15 (04) :595-597