GENOTOXICITY OF THE BOLDINE APORPHINE ALKALOID IN PROKARYOTIC AND EUKARYOTIC ORGANISMS

被引：19

作者：

MORENO, PRH

VARGAS, VMF

ANDRADE, HHR

HENRIQUES, AT

HENRIQUES, JAP

机构：

[1] UNIV FED RIO GRANDE SUL,INST BIOCIENCIAS,DEPT GENET,SETOR BIOFIS,BIO 3,RUA SARMENTO LEITE 500,BR-90049 PORTO ALEGRE,RS,BRAZIL

[2] UNIV FED RIO GRANDE SUL,CURSO POS GRADUACAO FARM,BR-90000 PORTO ALEGRE,RS,BRAZIL

[3] UNIV FED RIO GRANDE SUL,DEPT MEIO AMBIENTE,SECRETARIA SAUDE & MEIO AMBIENTE,BR-90000 PORTO ALEGRE,RS,BRAZIL

[4] UNIV FED RIO GRANDE SUL,DEPT FISIOL FARMACOL & BIOFIS,BR-90000 PORTO ALEGRE,RS,BRAZIL

来源：

MUTATION RESEARCH | 1991年 / 260卷 / 02期

关键词：

BOLDINE; AMES TEST; SOS CHROMOTEST; YEAST;

D O I：

10.1016/0165-1218(91)90002-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The aporphine alkaloid boldine, present in Peumus boldus (boldo-do-Chile) widely used all over the world, was tested for the presence of genotoxic, mutagenic and recombinogenic activities in microorganisms. This alkaloid did not show genotoxic activity with or without metabolic activation in the SOS chromotest and Ames tester strains TA100, TA98 and TA102. It was not able to induce point and frameshift mutations in haploid Saccharomyces cerevisiae cells. However, mitotic recombinational events such as crossing-over and gene conversion were weakly induced in diploid yeast cells by this alkaloid. Also, boldine was able to induce weakly cytoplasmic 'petite' mutation in haploid yeast cells.

引用

页码：145 / 152

页数：8

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