Post-transplant lymphoproliferative disorder: case report and review of susceptibility to EBV in the Scottish adult renal transplant pool

被引：0

作者：

Selvarajah, Viknesh ^{[1
]}

Lake, Katie ^{[1
]}

Robertson, Sue ^{[1
]}

Carman, William ^{[2
]}

Isles, Chris ^{[1
]}

机构：

[1] Dumfries & Galloway Royal Infirm, Dept Renal Med, Dumfries DG1 4AP, Scotland

[2] Gartnavel Royal Hosp, West Scotland Specialist Virol Lab, Glasgow G12 0ZA, Lanark, Scotland

来源：

CLINICAL KIDNEY JOURNAL | 2009年 / 2卷 / 01期

关键词：

EBV; CMV; PTLD; renal; transplantation;

D O I：

10.1093/ndtplus/sfn180

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of high-grade non-Hodgkin's lymphoma following Epstein-Barr virus (EBV) infection in a 38-year-old renal transplant recipient who was successfully treated with rituximab and remains alive 6 years later with reasonable graft function. We subsequently undertook a survey showing that 1.8% of the Scottish adult transplant pool are susceptible to EBV infection. Though a vaccine for EBV is currently not yet available, routine screening of potential renal transplant recipients for EBV should help identify those at increased risk of post-transplant lymhoproliferative disorder (PTLD), while tailoring of immunosuppression and antiviral prophylaxis with Ganciclovir may help reduce the emergence of this potentially life-threatening disease.

引用

页码：52 / 54

页数：3

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