MicroRNA as a Novel Modulator in Head and Neck Squamous Carcinoma

被引：13

作者：

Chen, Li-Hsin ^{[1
,2
]}

Tsai, Kun-Ling ^{[2
,3
]}

Chen, Yi-Wei ^{[3
]}

Yu, Cheng-Chia ^{[4
]}

Chang, Kuo-Wei ^{[5
,6
]}

Chiou, Shi-Hwa ^{[1
,2
,3
]}

Ku, Hung-Hai ^{[7
]}

Chu, Pen-Yuan ^{[8
,9
]}

Tseng, Ling-Ming ^{[10
]}

Huang, Pin-I ^{[3
,11
]}

Lo, Wen-Liang ^{[5
,6
]}

机构：

[1] Natl Yang Ming Univ, Inst Pharmacol, Taipei 11221, Taiwan

[2] Taipei Vet Gen Hosp, Dept Med Res & Educ, Taipei 11217, Taiwan

[3] Natl Yang Ming Univ, Inst Clin Med, Sch Med, Taipei 11221, Taiwan

[4] Chung Shan Med Univ, Inst Oral Biol & Biomat Sci, Taichung 40201, Taiwan

[5] Natl Yang Ming Univ, Sch Dent, Dept Dent, Taipei 11221, Taiwan

[6] Taipei Vet Gen Hosp, Div Oral & Maxillofacial Surg, Dept Stomatol, Taipei 11217, Taiwan

[7] Natl Yang Ming Univ, Inst Anat & Cell Biol, Taipei 11221, Taiwan

[8] Natl Yang Ming Univ, Sch Med, Taipei 11221, Taiwan

[9] Taipei Vet Gen Hosp, Dept Otolaryngol, Otolaryngol & Head & Neck Surg, Taipei 11217, Taiwan

[10] Taipei Vet Gen Hosp, Dept Surg, Taipei 11217, Taiwan

[11] Taipei Vet Gen Hosp, Ctr Canc, Taipei 11217, Taiwan

来源：

JOURNAL OF ONCOLOGY | 2010年 / 2010卷

关键词：

D O I：

10.1155/2010/135632

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs have emerged as important regulators of cell proliferation, development, cancer formation, stress responses, cell death, and other physiological conditions in the past decade. On the other hand, head and neck cancer is one of the top ten most common cancers worldwide. Recent advances in microRNAs have revealed their prominent role in regulating gene expression and provided new aspects of applications in diagnosis, prognosis, and therapeutic strategies in head and neck squamous carcinoma. In the present paper, we focus on microRNAs showing significant differences between normal and tumor cells or between cells with differential ability of metastasis. We also emphasize specific microRNAs that could modulate tumor cell properties, such as apoptosis, metastasis, and proliferation. These microRNAs possess the potential to be applied on clinical therapy in the future.

引用

页数：15

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