Regulation of rat liver type 1 iodothyronine deiodinase mRNA levels by testosterone

被引：42

作者：

Miyashita, K

Murakami, M

Iriuchijima, T

Takeuchi, T

Mori, M

机构：

[1] GUNMA UNIV,SCH MED,DEPT INTERNAL MED 1,MAEBASHI,GUMMA 371,JAPAN

[2] GUNMA UNIV,INST MOLEC & CELLULAR REGULAT,MAEBASHI,GUMMA 371,JAPAN

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1995年 / 115卷 / 02期

关键词：

iodothyronine deiodinase; mRNA; testosterone; estradiol; liver; hepatocyte culture;

D O I：

10.1016/0303-7207(95)03689-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

To investigate the underlying mechanisms of sex-related differences in liver type 1 iodothyronine deiodinase (ID1), we studied the sex-related differences and roles of sex steroids in liver ID1 mRNA levels in the rat. In both euthyroid and thyroidectomized rats, liver ID1 activity and ID1 mRNA levels in female rats were less than those in male rats. A positive correlation was observed between liver ID1 activity and ID1 mRNA levels. Liver ID1 activity and ID1 mRNA levels in male rats decreased after orchiectomy, and were increased to control levels by testosterone administration. Ovariectomy or beta-estradiol administration did not alter liver ID1 activity or ID1 mRNA levels in female rats. ID1 mRNA levels in cultured rat hepatocytes were significantly increased by testosterone, but not by beta-estradiol. These results suggest that the sex-related differences in liver ID1 activity are attributable to differences in ID1 mRNA levels, and that testosterone plays an important role in the sex-related differences in liver ID1 mRNA levels.

引用

页码：161 / 167

页数：7

共 16 条

[1] THYROID-HORMONE REGULATES TYPE-I DEIODINASE MESSENGER-RNA IN RAT-LIVER [J].