Calcium channels as target sites of heavy metals

被引:85
作者
Busselberg, D
机构
[1] Heinrich Heine-University Düsseldorf, Physiology II, 40225 Düsseldorf, Moorenstraße S
关键词
voltage-activated calcium channel currents (VACCCs); NMDA-activated channel currents (NACCs); lead (Pb); mercury (Hg); methylmercury (MeHg); aluminum (Al); zinc (Zn);
D O I
10.1016/0378-4274(95)03559-1
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Zinc (Zn), aluminium (Al), mercury (Hg), methylmercury (MeHg) and lead (Pb) extracellulary applied reduce voltage-activated calcium channel currents (VACCCs); Ph and Al also reduce N-methyl-D-aspartate (NMDA)-activated channel currents (NACCs). Pb is most effective in reducing VACCCs, with an IC50 of 0.46 mu M, followed by Hg (IC50 = 1.1 mu M) and MeHg (IC50 = 2.6 mu M). Zn and Al were less potent (IC50 = 69 and 84 mu M, respectively). Al acts on channels in the open state; its effect is pH dependent. The effects of Ph were specific for VACCCs and NACCs. Hg, Al and Zn had only minor effects on voltage-activated potassium and sodium channels, while MeHg reduced potassium channel currents (IC50 = 2.2 mu M) and, at higher concentrations, sodium channel currents (IC50 = 12.3 mu M). Al also reduced other receptor-activated channel currents. These results demonstrate that a variety of metal species produce different actions at the level of the cell membrane.
引用
收藏
页码:255 / 261
页数:7
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