MECAMYLAMINE BLOCKADE OF NICOTINE RESPONSES - EVIDENCE FOR 2 BRAIN NICOTINIC RECEPTORS

被引：71

作者：

COLLINS, AC

EVANS, CB

MINER, LL

MARKS, MJ

机构：

[1] UNIV COLORADO, SCH PHARM, INST BEHAV GENET, CAMPUS BOX 447, BOULDER, CO 80309 USA

[2] UNIV COLORADO, DEPT PSYCHOL, BOULDER, CO 80309 USA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1986年 / 24卷 / 06期

关键词：

D O I：

10.1016/0091-3057(86)90518-6

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Mice of two inbred strains, DBA and C3H, were pretreated with mecamylamine before challenge with nicotine. Mecamylamine blocked nicotine-induced seizures, enhanced startle, and alterations in respiratory rate, Y-maze activity, heart rate and body temperature. Mecamylamine blocked nicotine-induced seizures and enhanced startle with IC50 values of less than 0.1 mg/kg. The other nicotine effects were blocked by mecamylamine with IC50 values between 0.8 and 2.8 mg/kg. Strain differences in sensitivity to mecamylamine blockade were also detected. These results suggest that nicotine elicits its effects at two receptors, which may be those labeled with [125I]-.alpha.-bungarotoxin and with [3H]-nicotine.

引用

页码：1767 / 1773

页数：7

共 30 条

[1] SITES AND MECHANISMS FOR NICOTINES ACTION IN THE BRAIN [J].