Delivery of growth factor-associated genes to mesenchymal stem cells for cartilage and bone tissue regeneration

被引：0

作者：

Ahn, Jongchan ^{[1
]}

Park, Seah ^{[1
]}

Cha, Byung-Hyun ^{[1
]}

Kim, Jae Hwan ^{[1
]}

Park, Hansoo ^{[2
]}

Joung, Yoon Ki ^{[1
,2
]}

Han, Inbo ^{[3
]}

Lee, Soo-Hong ^{[1
]}

机构：

[1] CHA Univ, Dept Biomed Sci, Pocheon Si, Gyeonggi Do, South Korea

[2] Chung Ang Univ, Dept Integrat Engn, Seoul, South Korea

[3] CHA Univ, Bundang Med Ctr, Dept Neurosurg, Pocheon Si, Gyeonggi Do, South Korea

来源：

BIOMATERIALS AND BIOMECHANICS IN BIOENGINEERING | 2014年 / 1卷 / 03期

关键词：

growth factor; transcription factor; genetically-modified mesenchymal stem cells; cartilage; bone; tissue regeneration;

D O I：

10.12989/bme.2014.1.3.151

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Genetically-modified mesenchymal stem cells (GM-MSCs) have emerged as promising therapeutic tools for orthopedic degenerative diseases. GM-MSCs have been widely reported that they are able to increase bone and cartilage tissue regeneration not only by secreting transgene products such as growth factors in a long-term manner, also by inducing MSCs into tissue-specific cells. For example, MSCs modified with BMP-2 gene increased secretion of BMP-2 protein resulting in enhancement of bone regeneration, while MSCs with TGF-b gene did cartilage regeneration. In this review, we introduce several growth factors for gene delivery to MSCs and strategies for bone and cartilage tissue regeneration using GM-MSCs. Furthermore, we describe strategies for strengthening GM-MSCs to more intensively induce tissue regeneration by co-delivery system of multiple genes.

引用

页码：151 / 162

页数：12

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