CHONDRAMIDES-A-SIMILAR-TO-D, NEW ANTIFUNGAL AND CYTOSTATIC DEPSIPEPTIDES FROM CHONDROMYCES-CROCATUS (MYXOBACTERIA) - PRODUCTION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

被引：102

作者：

KUNZE, B ^{[1
]}

JANSEN, R ^{[1
]}

SASSE, F ^{[1
]}

HOFLE, G ^{[1
]}

REICHENBACH, H ^{[1
]}

机构：

[1] GESELL BIOTECHNOL FORSCH MBH,GBF,NATURSTOFFCHEM ABT,D-38124 BRAUNSCHWEIG,GERMANY

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 11期

关键词：

D O I：

10.7164/antibiotics.48.1262

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Novel depsipeptides, named chondramides were produced at levels up to 4.3 mg/liter by several myxobacteria of the genus Chondromyces. The compounds are structurally closely related to jaspamide/jasplakinolide from marine sponges of the genus Jaspis. Initially the chondramides were detected in acetone extracts of the biomass of Chondromyces crocatus, strain Cm c2. So far, four structural variants could be characterized, the chondramides A similar to D. They inhibited the growth of a few yeasts and showed high cytostatic activity against cultivated human and animal cells.

引用

页码：1262 / 1266

页数：5

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