THE INTERACTION BETWEEN NUCLEAR TOPOISOMERASE-II ACTIVITY FROM HUMAN-LEUKEMIA CELLS, EXOGENOUS DNA, AND 4'-(9-ACRIDINYLAMINO) METHANESULFON-M-ANISIDIDE (M-AMSA) OR 4-(4,6-0-ETHYLIDENE-BETA-D-GLUCOPYRANOSIDE) (VP-16) INDICATES THE SENSITIVITY OF THE CELLS TO THE DRUGS

被引：50

作者：

ESTEY, EH ^{[1
]}

SILBERMAN, L ^{[1
]}

BERAN, M ^{[1
]}

ANDERSSON, BS ^{[1
]}

ZWELLING, LA ^{[1
]}

机构：

[1] UNIV TEXAS,MD ANDERSON HOSP & TUMOR INST,DIV MED,DEPT MED ONCOL,HOUSTON,TX 77030

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1987年 / 144卷 / 02期

关键词：

D O I：

10.1016/S0006-291X(87)80033-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：787 / 793

页数：7

共 16 条

[1] THE PRODUCTION OF TOPOISOMERASE-II-MEDIATED DNA CLEAVAGE IN HUMAN-LEUKEMIA CELLS PREDICTS THEIR SUSCEPTIBILITY TO 4'-(9-ACRIDINYLAMINO)METHANESULFON-M-ANISIDIDE (M-AMSA) [J].

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ZWELLING, LA .

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[2]

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[8] ISOLATION OF INTERCALATOR-DEPENDENT PROTEIN-LINKED DNA STRAND CLEAVAGE ACTIVITY FROM CELL-NUCLEI AND IDENTIFICATION AS TOPOISOMERASE-II [J].

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[9] MECHANISM OF ANTITUMOR DRUG-ACTION - POISONING OF MAMMALIAN DNA TOPOISOMERASE-II ON DNA BY 4'-(9-ACRIDINYLAMINO)-METHANESULFON-META-ANISIDIDE [J].

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (05) :1361-1365

[10]

POMMIER Y, 1986, CANCER RES, V46, P611

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