AN EXPERIMENTAL ASSESSMENT OF CYANIDE CHALLENGE DOSE-RESPONSE, TIME-COURSE AND RECOVERY OF INDICATIVE TOXICITY PARAMETERS

被引：3
|
作者：
BUZALEH, AM [1 ]
VAZQUEZ, ES [1 ]
BATLLE, AMD [1 ]
机构：
[1] UNIV BUENOS AIRES,FAC CIENCIAS EXACTAS & NAT,CTR NACL INVEST CIENT & TECN CTR,BUENOS AIRES,ARGENTINA
来源：
GENERAL PHARMACOLOGY | 1990年 / 21卷 / 06期
关键词：
D O I：
10.1016/0306-3623(90)90442-O
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. 1. Several sub-lethal doses of cyanide were assayed with the aim of obtaining significant differences in the parameters studied. A dose of 4 mg/kg s.c. was selected. 2. 2. Present studies were carried out to determine the time dependence of the effects produced by s.c. administration of a single dose of potassium cyanide as well as the recovery time of some of the toxicity indicative parameters. 3. 3. It was found that cyanide effects continued for at least 3 days; after the parameters had recovered normal values. © 1990.
引用
收藏
页码：839 / 843
页数：5
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