EVIDENCE FOR DISTINCT BINDING-SITES IN THE CUMENE HYDROPEROXIDE-DEPENDENT METABOLISM OF BENZO[A]PYRENE CATALYZED BY CYTOCHROME-P-450

被引：8
作者：
CAVALIERI, E
WONG, A
ROGAN, E
机构：
来源：
BIOCHEMICAL PHARMACOLOGY | 1987年 / 36卷 / 04期
关键词：
D O I：
10.1016/0006-2952(87)90347-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：435 / 440
页数：6
相关论文
共 20 条
[1]   METABOLISM OF 6-SUBSTITUTED BENZO[A]PYRENE DERIVATIVES - O-DEALKYLATION AND REGIOSPECIFICITY IN AROMATIC HYDROXYLATION [J].
ALPERT, AJ ;
CAVALIERI, EL .
JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (08) :919-927
[2]  
CAVALIERI E, 1986, POLYNUCLEAR AROMATIC, P131
[3]  
CAVALIERI EL, 1985, POLYCYCLIC HYDROCARB, P289
[4]  
CONNEY AH, 1957, J BIOL CHEM, V228, P753
[5]   REGIOSELECTIVITY AND STEREOSELECTIVITY OF VARIOUS FORMS OF PURIFIED CYTOCHROME-P-450 IN METABOLISM OF BENZO[A]PYRENE AND (-) TRANS-7,8-DIHYDROXY-7,8-DIHYDROBENZO[A]PYRENE AS SHOWN BY PRODUCT FORMATION AND BINDING TO DNA [J].
DEUTSCH, J ;
LEUTZ, JC ;
YANG, SK ;
GELBOIN, HV ;
CHIANG, YL ;
VATSIS, KP ;
COON, MJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (07) :3123-3127
[6]  
FASCO MJ, 1978, J BIOL CHEM, V253, P7813
[7]  
GUENGERICH FP, 1977, J BIOL CHEM, V252, P3970
[8]   EFFECTS OF INDUCERS AND EPOXIDE HYDRASE ON METABOLISM OF BENZO[A]PYRENE BY LIVER-MICROSOMES AND A RECONSTITUTED SYSTEM - ANALYSIS BY HIGH PRESSURE LIQUID-CHROMATOGRAPHY [J].
HOLDER, G ;
YAGI, H ;
DANSETTE, P ;
JERINA, DM ;
LEVIN, W ;
LU, AYH ;
CONNEY, AH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (11) :4356-4360
[9]  
KINOSHITA N, 1973, CANCER RES, V33, P1937
[10]   AUTOXIDATION OF 6-HYDROXYBENZO[A]PYRENE AND 6-OXOBENZO[A]PYRENE RADICAL, REACTIVE METABOLITES OF BENZO[A]PYRENE [J].
LORENTZEN, RJ ;
CASPARY, WJ ;
LESKO, SA ;
TSO, POP .
BIOCHEMISTRY, 1975, 14 (18) :3970-3977
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