THE GENETIC-REGULATION OF APOPTOSIS

被引：256
作者：
WYLLIE, AH
机构：
[1] Cancer Research Campaign Laboratories, Department of Pathology, The University of Edinburgh Medical School, Edinburgh, EH8 9AG, Teviot Place
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 01期
关键词：
D O I：
10.1016/S0959-437X(95)90060-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Dramatic advances, most of them within the past two years, have provided a picture of the genetic regulation of apoptosis in mammalian cells. Although much detail remains to be filled in, the general structure-concordant with programmed death in invertebrates - includes signalling systems, genetic determination of susceptibility, critical proteins capable of reversing or re-affirming the death sentence, and a common effector pathway driven by specific proteases.
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页码：97 / 104
页数：8
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