THE GEANT4-DNA PROJECT

被引：420

作者：

Incerti, S. ^{[1
,2
]}

Baldacchino, G. ^{[1
,3
]}

Bernal, M. ^{[1
,4
,11
]}

Capra, R. ^{[1
]}

Champion, C. ^{[1
,5
]}

Francis, Z. ^{[1
,6
]}

Gueye, P. ^{[1
,7
]}

Mantero, A. ^{[1
,2
]}

Mascialino, B. ^{[1
,8
]}

Moretto, P. ^{[1
,2
]}

Nieminen, P. ^{[1
,9
]}

Villagrasa, C. ^{[1
,6
]}

Zacharatou, C. ^{[1
,10
]}

机构：

[1] Geant4 DNA Collaborat, Chemin Solarium,BP 120, F-33175 Gradignan, France

[2] Univ Bordeaux 1, CNRS, IN2P3, CENBG, F-33175 Gradignan, France

[3] CEA Saclay, IRAMIS, CNRS, CEA,UMR3299,SIS2M,Lab Radiolyse, F-91191 Gif Sur Yvette, France

[4] Univ Simon Bolivar, Dept Fis, Caracas, Venezuela

[5] Univ Paul Verlaine Metz, Lab Phys Mol & Collis, F-57078 Metz, France

[6] IRSN, F-92262 Fontenay Aux Roses, France

[7] Hampton Univ, Dept Phys, Hampton, VA 23668 USA

[8] Karolinska Inst, S-17176 Stockholm, Sweden

[9] ESA ESTEC, NL-2200 AG Noordwijk, Netherlands

[10] Niels Bohr Inst, DK-2100 Copenhagen, Denmark

[11] Univ Estado Rio de Janeiro, Lab Ciencias Radiol, Rio De Janeiro, Brazil

来源：

INTERNATIONAL JOURNAL OF MODELING SIMULATION AND SCIENTIFIC COMPUTING | 2010年 / 1卷 / 02期

关键词：

Monte-Carlo; Geant4; microdosimetry; nanodosimetry; radiobiology;

D O I：

10.1142/S1793962310000122

中图分类号：

TP301 [理论、方法];

学科分类号：

081202 ;

摘要：

The Geant4-DNA project proposes to develop an open-source simulation software based and fully included in the general-purpose Geant4 Monte-Carlo simulation toolkit. The main objective of this software is to simulate biological damages induced by ionizing radiations at the cellular and sub-cellular scale. This project was originally initiated by the European Space Agency for the prediction of the deleterious effects of radiations that may affect astronauts during future long duration space exploration missions. In this paper, the Geant4-DNA collaboration presents an overview of the whole on-going project, including its most recent developments that are available in the Geant4 toolkit since December 2009 (release 9.3), as well as an illustration example simulating the direct irradiation of a biological chromatin fiber. Expected extensions involving several research domains, such as particle physics, chemistry and cellular and molecular biology, within a fully interdisciplinary activity of the Geant4 collaboration are also discussed.

引用

页码：157 / 178

页数：22

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