Stem cell technology for bone regeneration: current status and potential applications

被引:67
作者
Asatrian, Greg [1 ,2 ]
Pham, Dalton [1 ,2 ,3 ]
Hardy, W. Inters R. [4 ,5 ]
James, Aaron W. [1 ,2 ,3 ,4 ,5 ]
Peault, Bruno [4 ,5 ,6 ]
机构
[1] Univ Calif Los Angeles, Sch Dent, Dent & Craniofacial Res Inst, Los Angeles, CA 90024 USA
[2] Univ Calif Los Angeles, Sch Dent, Sect Orthodont, Los Angeles, CA 90024 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90024 USA
[4] Univ Calif Los Angeles, Orthopaed Hosp, Dept Orthopaed Surg, Los Angeles, CA 90024 USA
[5] Orthopaed Hosp Res Ctr, Los Angeles, CA USA
[6] MRC, Ctr Regenerat Med, Edinburgh, Midlothian, Scotland
基金
英国医学研究理事会;
关键词
mesenchymal stem cell; pericyte; bone tissue engineering; MSC; ASC; DMSC;
D O I
10.2147/SCCAA.S48423
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Continued improvements in the understanding and application of mesenchymal stem cells (MSC) have revolutionized tissue engineering. This is particularly true within the field of skeletal regenerative medicine. However, much remains unknown regarding the native origins of MSC, the relative advantages of different MSC populations for bone regeneration, and even the biologic safety of such unpurified, grossly characterized cells. This review will first summarize the initial discovery of MSC, as well as the current and future applications of MSC in bone tissue engineering. Next, the relative advantages and disadvantages of MSC isolated from distinct tissue origins are debated, including the MSC from adipose, bone marrow, and dental pulp, among others. The perivascular origin of MSC is next discussed. Finally, we briefly comment on pluripotent stem cell populations and their possible application in bone tissue engineering. While continually expanding, the field of MSC-based bone tissue engineering and regeneration shows potential to become a clinical reality in the not-so-distant future.
引用
收藏
页码:39 / 48
页数:10
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