OPPOSITE CHANGES IN THE CONTENT OF OXYTOCIN-LIKE AND VASOPRESSIN-LIKE IMMUNOREACTIVE PEPTIDES IN THE RAT THYMUS DURING AGING

被引：11
作者：
MELIS, MR [1 ]
MAURI, A [1 ]
ARGIOLAS, A [1 ]
机构：
[1] UNIV CAGLIARI, INST OBSTET & GYNECOL, I-09124 CAGLIARI, ITALY
来源：
REGULATORY PEPTIDES | 1995年 / 59卷 / 03期
关键词：
THYMUS; OXYTOCIN; VASOPRESSIN; AGING; RIA; HPLC; RAT;
D O I：
10.1016/0167-0115(95)00088-S
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The content of oxytocin- and vasopressin-like immunoreactive (IR) peptides was measured in the thymic extract of 2, 5, 10, 15 and 20 month-old rats by radioimmunoassay before or after fractionation by high-pressure liquid chromatography. In both cases the content of the oxytocin-like IR peptide, which behaved like authentic oxytocin in the chromatography column, increased during aging. Compared to 2 month-old rats a significant 30% increase was observed in 5 month-old rats, whereas the maximal increase (200%) was found in 20 month-old rats. In contrast, the content of the vasopressin-like IR peptide, which behaved like authentic arg(8)-vasopressin in the chromatography column, decreased during aging. The decrease (30%) was evident in 5 month-old rats, and was maximal (80%) in 15 month-old rats. The present results suggest that the mechanisms regulating the content of oxytocin- and vasopressin-like IR peptides in the rat thymus undergo differential changes during aging. These processes might be linked to thymic involution.
引用
收藏
页码：335 / 340
页数：6
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