The novel monoclonal antibody By114 helps detect the early emergence of a paroxysmal nocturnal hemoglobinuria clone in aplastic anemia

被引：0

作者：

Tooze, JA ^{[1
]}

Saso, R ^{[1
]}

Marsh, JCW ^{[1
]}

Papadopoulos, A ^{[1
]}

Pulford, K ^{[1
]}

GordonSmith, EC ^{[1
]}

机构：

[1] UNIV OXFORD,JOHN RADCLIFFE HOSP,DEPT CELLULAR SCI,LRF IMMUNODIAGNOST GRP,OXFORD OX3 9DU,ENGLAND

来源：

EXPERIMENTAL HEMATOLOGY | 1995年 / 23卷 / 14期

关键词：

CD66c; aplastic anemia; paroxysmal nocturnal hemoglobinuria;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The newly described monoclonal antibody By114 has been used with flow cytometry to investigate the status of the 90-kD glycosylphosphatidyl-inositol (GPI)-anchored component of CD66 (CD66c) on neutrophils from nine patients with paroxysmal nocturnal hemoglobinuria (PNH), seven with aplastic anemia/PNH, and 63 with aplastic anemia (AA) and a negative Ham's test. We have found that By114 is a sensitive indicator for recognizing patients with PNH and has helped delineate a group of nine patients with aplastic anemia and a negative Ham's test who have evidence of a larger PNH done than indicated by other monoclonal antibodies (mAbs). By 114 is a valuable marker for detecting the emergence of a PNH clone before the Ham's test becomes positive and is a more sensitive detector of deficient GPI-anchored proteins than other mAbs.

引用

页码：1484 / 1491

页数：8