DOMINANT GENES FOR COLORECTAL-CANCER ARE NOT RARE

被引：111
作者：
HOULSTON, RS
COLLINS, A
SLACK, J
MORTON, NE
机构：
[1] CRC Research Group in Genetic Epidemiology, Department of Community Medicine, Southampton General Hospital, Southampton
来源：
ANNALS OF HUMAN GENETICS | 1992年 / 56卷
关键词：
D O I：
10.1111/j.1469-1809.1992.tb01136.x
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The genetic basis for colorectal cancer was investigated by complex segregation analysis of a published series of consecutive pedigrees ascertained through patients undergoing treatment for colorectal cancer. Analysis favoured a dominant gene or genes with a frequency of 0.006 with a lifetime penetrance of 0.63. These genes account for 81 % of colorectal cancer in patients under 35, however, by 65 about 85 % are phenocopies.
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页码：99 / 103
页数：5
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