AUTOANTIBODIES IN WOMEN WITH PRIMARY RECURRENT SPONTANEOUS-ABORTION OF UNKNOWN ETIOLOGY

被引：65

作者：

KWAK, JYH ^{[1
]}

GILMANSACHS, A ^{[1
]}

BEAMAN, KD ^{[1
]}

BEER, AE ^{[1
]}

机构：

[1] UNIV HLTH SCI CHICAGO MED SCH,DEPT OBSTET & GYNECOL,N CHICAGO,IL 60064

来源：

JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1992年 / 22卷 / 01期

关键词：

AUTOANTIBODY; PRIMARY ABORTER; PHOSPHOLIPID;

D O I：

10.1016/0165-0378(92)90003-M

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A group of 153 women with 3 or more recurrent spontaneous abortions (RSAs) with unknown etiology and 90 normal multigravida controls were evaluated for antibodies to phospholipids and nuclear antigens. We demonstrate that women with recurrent spontaneous abortions showed significantly higher incidence of antibodies to phospholipids than normal multigravida controls. In contrast, the incidence of antibodies to polynucleotides and histones was not different between these two groups. These findings suggest that antiphospholipid antibodies are either epiphenomena or causally related to recurrent spontaneous abortions.

引用

页码：15 / 31

页数：17

共 28 条

[1]

BARBUI T, 1988, FERTIL STERIL, V50, P589

[2]

BEER AE, 1981, AM J OBSTET GYNECOL, V141, P987

[3]

BEER AE, 1990, MOL CELLULAR BIOL MA, P285

[4] INDUCTION OF ANTIPHOSPHOLIPID SYNDROME IN NAIVE MICE WITH MOUSE LUPUS MONOCLONAL AND HUMAN POLYCLONAL ANTICARDIOLIPIN ANTIBODIES [J].

BLANK, M ;

COHEN, J ;

TODER, V ;

SHOENFELD, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (08) :3069-3073

[5] OBSTETRIC COMPLICATIONS ASSOCIATED WITH THE LUPUS ANTICOAGULANT [J].

BRANCH, DW ;

SCOTT, JR ;

KOCHENOUR, NK ;

HERSHGOLD, E .

NEW ENGLAND JOURNAL OF MEDICINE, 1985, 313 (21) :1322-1326

[6] IMMUNOGLOBULIN-G FRACTIONS FROM PATIENTS WITH ANTIPHOSPHOLIPID ANTIBODIES CAUSE FETAL DEATH IN BALB/C MICE - A MODEL FOR AUTOIMMUNE FETAL LOSS [J].

BRANCH, DW ;

DUDLEY, DJ ;

MITCHELL, MD ;

CREIGHTON, KA ;

ABBOTT, TM ;

HAMMOND, EH ;

DAYNES, RA .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1990, 163 (01) :210-216

[7]

CARIOU R, 1988, THROMB HAEMOSTASIS, V60, P54

[8]

COULHAM CB, 1991, AM J REPROD IMMUNOL, V25, P1

[9] PATERNAL MONONUCLEAR CELL IMMUNIZATION THERAPY FOR REPEATED MISCARRIAGE - PREDICTIVE VARIABLES FOR PREGNANCY SUCCESS [J].

COWCHOCK, FS ;

SMITH, JB ;

DAVID, S ;

SCHER, J ;

BATZER, F ;

CORSON, S .

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 1990, 22 (1-2) :12-17

[10] ANTIBODIES TO PHOSPHOLIPIDS AND NUCLEAR ANTIGENS IN PATIENTS WITH REPEATED ABORTIONS [J].

COWCHOCK, S ;

SMITH, JB ;

GOCIAL, B .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1986, 155 (05) :1002-1010

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