RELATIONSHIP BETWEEN THE HYDROPHOBIC AND HYDROPHILIC MOLECULAR-PARAMETERS OF SOME SYNTHETIC NUCLEOSIDES, DETERMINED BY MEANS OF ADSORPTIVE AND REVERSED-PHASE THIN-LAYER CHROMATOGRAPHY

被引：11
作者：
CSERHATI, T
VALKO, K
机构：
[1] Central Research Institute for Chemistry, Hungarian Academy of Sciences, H-1525 Budapest
来源：
JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS | 1990年 / 20卷 / 02期
关键词：
D O I：
10.1016/0165-022X(90)90067-M
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The adsorption capacity, the specific adsorptive surface, the lipophilicity and the specific hydrophobic surface of 59 natural and synthetic nucleoside derivatives were determined by means of adsorptive chromatography and reversed-phase thin-layer chromatography for the future application of these molecular parameters in quantitative structure-activity relationship studies. Stepwise regression analysis and principal component analysis proved that each of the physico-chemical parameters has a different information content, and their application in the design of new bioactive derivatives is therefore justified. © 1990.
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页码：81 / 95
页数：15
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