HYPERFIBRINOLYSIS DURING INTRACRANIAL SURGERY - EFFECT OF HIGH-DOSE APROTININ

被引：33

作者：

PALMER, JD ^{[1
]}

FRANCIS, DA ^{[1
]}

ROATH, OS ^{[1
]}

FRANCIS, JL ^{[1
]}

IANNOTTI, F ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON,DEPT HAEMATOL,SOUTHAMPTON,HANTS,ENGLAND

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1995年 / 58卷 / 01期

关键词：

HYPERFIBRINOLYSIS; INTRACRANIAL SURGERY; APROTININ;

D O I：

10.1136/jnnp.58.1.104

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A patient undergoing intracranial surgery developed disseminated intravascular coagulation with life threatening peroperative bleeding. Thromboelastography established the diagnosis of hyperfibrinolysis, usually a fatal complication of a neurosurgical operation. With the administration of a high dose regimen of aprotinin (Trasylol(R)) the haemorrhage was controlled and the hyperfibrinolytic state reversed. Evaluation of blood samples from the jugular bulb suggested that there was a pronounced local release of tissue plasminogen activator into the circulation.

引用

页码：104 / 106

页数：3

共 6 条

[1]

BIDSTRUP BP, 1989, J THORAC CARDIOV SUR, V97, P364

[2]

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[3]

KALTER RD, 1979, J THORAC CARDIOV SUR, V77, P427

[4]

KAUFMANN HH, 1982, NEUROSURGERY, V7, P445

[5]

KRATZER MAA, 1991, TRANSPL P, V23, P1906

[6] BIOLOGICAL SIGNIFICANCE OF TISSUE PLASMINOGEN-ACTIVATOR CONTENT IN BRAIN-TUMORS [J].

SAWAYA, R ;

RAMO, OJ ;

SHI, ML ;

MANDYBUR, G .

JOURNAL OF NEUROSURGERY, 1991, 74 (03) :480-486

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