SPECTROPHOTOMETRIC DETERMINATION OF PHARMACEUTICAL DOSAGES BY PARTIAL LEAST-SQUARES CALIBRATION

被引：28

作者：

BLANCO, M

COELLO, J

GONZALEZ, F

ITURRIAGA, H

MASPOCH, S

TOMAS, X

机构：

[1] Departamento de Química, Unidad de Química Analítica, Universidad Autónoma de Barcelona, E-08193 Bellaterra, Barcelona

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1994年 / 12卷 / 04期

关键词：

PARTIAL LEAST-SQUARES CALIBRATION; SIMULTANEOUS DETERMINATION; UV SPECTROPHOTOMETRY; METHYLPARABEN; EBASTIN;

D O I：

10.1016/0731-7085(93)E0004-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Partial least-squares calibration was used for the spectrophotometric determination of the active compound and preservative in a syrup also containing several light absorbing excipients. The calibration matrix was constructed from laboratory-made mixtures of the analytes and excipients and was used to quantify three samples from different batches. The most suitable conditions for quantitation were determined and the results obtained are compared with those provided by HPLC.

引用

页码：509 / 514

页数：6

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