INSTABILITY OF THE MINISATELLITE SEQUENCE IN THE 1ST INTRON OF THE RAT RENIN GENE AND LOCALIZATION OF THE GENE TO CHROMOSOME 13Q1O BETWEEN FH AND PEPC LOCI

被引：7
作者：
MORI, M [1 ]
ISHIZAKI, K [1 ]
SERIKAWA, T [1 ]
YAMADA, J [1 ]
机构：
[1] KYOTO UNIV,CTR RADIAT BIOL,SAKYO KU,KYOTO 606,JAPAN
来源：
JOURNAL OF HEREDITY | 1992年 / 83卷 / 03期
关键词：
D O I：
10.1093/oxfordjournals.jhered.a111193
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A minisatellite sequence in the first intron of the rat renin gene showed five-allelic polymorphism in 11 inbred rat strains. A new allelic variant, which was thought to be generated in the germ line, was observed in 136 animals of two sets of backcross progenies originating from parental strains with different alleles. These facts suggested that the minisatellite is genetically unstable. A linkage analysis using the backcross progenies confirmed the assignment of renin locus (REN) on linkage group (LG) X at a site between FH (fumarate hydratase) and PEPC (peptidase) loci. Fluorescence in situ hybridization allowed mapping of the renin gene on rat chromosome 13q13.
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页码：204 / 207
页数：4
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